Applications of Ion Chromatography for Pharmaceutical and Biological Products

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2012 | 455 Pages | ISBN: 0470467096 | PDF | 5 MB
This is a comprehensive source of information on the application of ion chromatography (IC) in the analysis of pharmaceutical drugs and biologicals. This book, with contributors from academia, pharma, the biotech industry, and instrument manufacturing, presents the different perspectives, experience, and expertise of the thought leaders of IC in a comprehensive manner. It explores potential IC applications in different aspects of product development and quality control testing. In addition, an appendix section gives information on critical physical and chromatographic parameters related to IC and information on current manufacturers of IC systems, columns, and other components.Content: Chapter 1 Ion Chromatography-Principles and Applications (pages 1-21): Lokesh BhattacharyyaChapter 2 Retention Processes in Ion?Exclusion Chromatography: A New Perspective (pages 23-47): Milko Novic and Paul R. HaddadChapter 3 Pulsed Electrochemical Detection in Ion Chromatography (pages 49-90): William R. LacourseChapter 4 Suppressor Design and Detection for Ion Chromatography (pages 91-105): Kannan Srinivasan, Sheetal Bhardwaj, Rong Lin and Christopher PohlChapter 5 Modelling and Optimization of Ion Chromatographic Separations of Pharmaceutically Relevant Organic Ions (pages 107-133): Philip Zakaria, Greg Dicinoski, Melissa Hanna?Brown and Paul R. HaddadChapter 6 Ion Chromatography in Pharmaceutical Drug Analysis (pages 135-157): Lokesh BhattacharyyaChapter 7 Analysis for Impurities by Ion Chromatography (pages 159-174): Shreekant V. KarmarkarChapter 8 Ion Chromatography Analysis of Aminoglycoside Antibiotics (pages 175-192): Valoran P. Hanko and Jeffrey S. RohrerChapter 9 Use of Cation?Exchange Ion Chromatography in the Analysis of Pharmaceuticals (pages 193-220): Christopher Pohl, Maria Rey and Rosanne SlingsbyChapter 11 High Performance Ion Chromatographic Analysis of Cholinergic Compounds: Carbachol and Bethanechol, and Associated Degradation Products (pages 237-245): David TrowbridgeChapter 12 Ion Chromatographic Analysis of Pharmaceuticals for Authenticity and Adulteration (pages 247-257): David S. JacksonChapter 13 Ion Chromatography of Drug Product Counter?Ions and other Ions in Drug Products (pages 259-269): Brian M. De Borba and Jeffrey S. RohrerChapter 14 Sample Preparation Techniques in Ion Chromatography for Pharmaceutical Applications (pages 271-283): Jay GandhiChapter 15 Validation of Ion Chromatographic Methods (pages 285-308): Shreekant V. KarmarkarChapter 16 Pharmacopeial Applications of Ion Chromatography (pages 309-320): Ravi RavichandranChapter 10 Comprehensive Approaches for Measurement of Active Pharmaceutical Ingredients, Counter?Ions, and Excipients Using HPLC with Charged Aerosol Detection (pages 221-236): Christopher Crafts, Bruce Bailey, Paul Gamache, Xiaodong Liu and Ian AcworthChapter 17 Glycan Analysis by High Performance Anion Exchange Chromatography with Pulsed Amperometric Detection (pages 321-338): Lokesh BhattacharyyaChapter 18 Monosaccharide Analysis of Glycoproteins by High?Performance Anion?Exchange Chromatography with Pulsed Amperometric Detection (pages 339-350): Jeffrey S. RohrerChapter 19 Two?Dimensional Ion Chromatography for Simultaneous Determination of Amino Acids and Carbohydrates (pages 351-364): Petr Jandik and Jun ChengChapter 20 Monitoring Protein N?Glycosylation Consistency Using HPAEC?PAD (pages 365-377): Carl GreyChapter 21 Oligosaccharide Analysis by High?Performance Anion?Exchange Chromatography Hyphenated to Integrated Pulsed Amperometric Detection and On?Line Ion?Trap Mass Spectrometry (pages 379-391): Cees BrugginkChapter 22 Applications of Ion Chromatography in Biological Product Analyses (pages 393-421): Alfred V. Del Grosso and Brandon DuongChapter 23 High Performance Anion?Exchange Chromatography with Pulsed Amperometric Detection (HPAEC?PAD) Analysis of GBS Glycoconjugate Vaccines: From Fermentation to Final Product (pages 423-434): Stefano Ricci, Barbara Fabbri, Sara Giannini, Silvia Bernardini, Marcello Morelli and Sandro D'AscenziChapter 24 Stability Studies and Characterization of Meningococcal A, C, Y, and W135 Glycoconjugate Vaccine (pages 435-447): Valeria Carinci, Alberto Bernardini, Cristiana Campa, Claudia Magagnoli, Francesca Beccai and Sandro D'Ascenzi


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